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Forever in your prime

Anything I find interesting about how to slow, prevent, and reverse aging.

Thursday, April 06, 2006

AGE Crosslink breaker


I don't know how many people know about this product, but it is currently only under trials for heart conditions and erectile disfunction.  Seems to me it has a good fit in Aubrey's SENS plan.  I'd like to see someone do testing with it to see if it helps longevity in mice.

Alagebrium is the only A.G.E. Crosslink Breaker in advanced human testing. The compound has demonstrated promising results in several Phase 2 human clinical trials and is being developed initially for cardiovascular and vascular diseases. Results to date suggest that alagebrium may be a novel therapy for a number of conditions that occur as a result of myocardial or vascular alterations associated with aging or diabetes. Preliminary evidence suggests that the compound is able to modify both the structure and function of the left ventricle (main pumping chamber of the heart) consistent with a partial reversal of pathology. Similarly, alagebrium has been shown to improve the reactivity and function of the arterial system. In addition, in all clinical testing to date, the compound has demonstrated a clean safety profile.