CR in primates

Diet, aging study gains $7.9 million grant
June 13, 2006
by Terry Devitt

[...]

At this point in the study, the disparities between the monkeys on a diet reduced in calories by 30 percent and those allowed to eat as much as they wish are clearly evident. "Most importantly, we're starting to see the separation of the survival curves," Weindruch says, noting that 90 percent of the animals who began the study on a reduced diet are still alive, while only 70 percent of the animals allowed to eat freely have survived to this stage.

[...]

The animals on a restricted diet exhibit 70 percent less body fat, and the fat tissue itself, Weindruch notes, is very different from the fat tissue in the control animals, those allowed to eat freely. His group has also observed that the animals that eat less have less insulin in their bloodstreams and less insulin resistance, which are opposite to increases seen in these hallmarks of type 2 diabetes.
"So far, we've had complete protection from type 2 diabetes," Weindruch explains. "Normally, 30 percent of the animals in a research colony will exhibit type 2 diabetes."